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KMID : 0368120110410080490
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Korean Circulation Journal
2011 Volume.41 No. 8 p.490 ~ p.493
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Hemorrhagic Transformation of Ischemic Stroke: Severe Complications of Prosthetic Valve Endocarditis
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Kim Jin-Sun
Yang Woo-In
Shim Chi-Young
Ha Jong-Won
Chung Nam-Sik
Chang Hyuk-Jae
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Abstract
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Ischemic stroke is a common complication of infective endocarditis (IE), occurring in 20-40% of left side IE cases. In these subsets, anticoagulation therapy may provoke hemorrhagic transformation (HT) of ischemic stroke, and complications of this magnitude deteriorate the clinical course for IE patients. However, in cases of IE complicated with a mechanical prosthetic valve, the physician can be concerned over the maintenance of anticoagulation due to the risk of thrombotic complication. According to our retrospective review, HT of ischemic stroke in prosthetic valve endocarditis occurred 13.8% (4/29) of the time in a variety of situations. Some of these even arose in patients with a subtherapeutic range of prothrombin time.
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KEYWORD
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Heart valve prosthesis, Endocarditis, Stroke, Cerebral hemorrhage, Anticoagulants
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