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KMID : 0368120120420050345
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Korean Circulation Journal
2012 Volume.42 No. 5 p.345 ~ p.348
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Recurrent Deep Vein Thrombosis due to Thrombophilia
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Afzalur Rahman
AKM Monwarul Islam
SAM Husnayen
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Abstract
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Deep vein thrombosis (DVT) is a common condition that is often under-diagnosed. Acquired or hereditary defects of coagulation or a combination of these defects may facilitate the development of DVT. Recurrent DVT, a positive family history or unusual presentation may warrant investigation for hereditary thrombophilia. Investigations are best when conducted at least one month after completion of a course of anticoagulant therapy. Most patients are managed with heparin in the acute stage overlapped by warfarin. The case presented here describes a 40-year old man undergoing three episodes of DVT. Investigations revealed protein C and protein S deficiency. Protein C, protein S and antithrombin deficiency either singly or in combination, are relatively common causes of hereditary thrombophilia. The case presented here serves as a reminder of the need to look into the underlying cause of venous thromboembolism.
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KEYWORD
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Deep vein thrombosis, Thrombophilia
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