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KMID : 0368120120420080551
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Korean Circulation Journal
2012 Volume.42 No. 8 p.551 ~ p.557
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Lack of Association Between Low Density Lipoprotein Particle Size and On-Treatment Platelet Reactivity in Patients With Coronary Artery Disease
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Kang Do-Yoon
Yang Han-Mo
Park Kyung-Woo
Lee So-Ryoung
Lee Min-Ho
Lee Dong-Won
Lee Hae-Young
Kang Hyun-Jae
Koo Bon-Kwon
Chae In-Ho
Choi Dong-Ju
Kim Hyo-Soo
Kim Cheol-Ho
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Abstract
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Background and Objectives: Small dense low density lipoproteins (sd-LDL) are a risk factor for coronary artery disease and are known to stimulate platelet function in vitro. This study aimed to evaluate whether high proportion of sd-LDL is associated with high on-treatment platelet reactivity (HOPR).
Subjects and Methods: From January 2009 to March 2010, 439 subjects (mean age: 64.3±9.7, Male : Female=306 : 133) were enrolled from the low density LIPOProtein-cholesterol Size measurement Registry with coronary artery disease, who had undergone elective percutaneous coronary intervention and measured both LDL particle size and on-treatment platelet reactivity (OPR). Mean LDL particle size was measured by gradient gel electrophoresis (Quantimetrix, Lipoprint™) and OPR by the VerifyNow™ system (aspirin and P2Y12).
Results: Between pattern A (large, buoyant LDL dominant) and B (sd-LDL dominant) population, there were no significant difference in OPR to aspirin (441.3±71.9 vs. 434.07±63.45 aspirin reaction units, p=0.351) or clopidogrel (237.9±87.3 vs. 244.9±80.7 P2Y12 reaction units, p=0.465). There was no difference in LDL particle size between patients with HOPR compared with non-HOPR patients (aspirin: 26.8±0.5 vs. 26.7±0.6 nm, p=0.078, clopidogrel: 26.7±0.6 vs. 26.8±0.5 nm, p=0.857). Pearson’s correlation coefficients between LDL particle size and platelet reactivity were not statistically significant (aspirin assay: r=0.080, p=0.098, P2Y12 assay: r=-0.027, p=0.568).
Conclusion: There was no significant association between LDL particle size and OPR in patients with coronary artery disease.
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KEYWORD
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Lipoproteins, Low-density lipoprotein, Platelet Function Tests
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