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KMID : 0368120120420090614
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Korean Circulation Journal
2012 Volume.42 No. 9 p.614 ~ p.617
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Urinary Levels of 8-Iso-Prostaglandin F2α and 8-Hydroxydeoxyguanine as Markers of Oxidative Stress in Patients With Coronary Artery Disease
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Kim Jang-Young
Lee Jun-Won
Youn Young-Jin
Ahn Min-Soo
Ahn Sung-Gyun
Yoo Byung-Su
Lee Seung-Hwan
Yoon Jung-Han
Choe Kyung-Hoon
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Abstract
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Background and Objectives : The objective of this study was to determine if urinary levels of 8-iso-prostaglandin F2α (8-iso-PGF2α) and 8-hydroxydeoxyguanine (8-OHdG) could be used as markers of the oxidative stress in significant coronary artery disease (CAD).
Subjects and Methods: We conducted a case-control study in 104 subjects assessed by coronary angiography with the following diagnoses: 35 consecutive cases of significant CAD and 69 cases of non-CAD with stable angina. We compared the urinary levels of 8-iso-PGF 2α and 8-OHdG, as measured by immunoassay between the 2 groups.
Results: History of hypertension was significantly higher and high density lipoprotein-cholesterol level significantly lower in the CAD group compared with those in the non-CAD group. Median levels of 8-iso-PGF2α were significantly higher in the CAD group compared with the non-CAD group (9.2 vs. 6.0 ng/mg, p=0.001). There were no significant differences in 8-OHdG values between the 2 groups. The odds ratio of 8-iso-PGF2α for CAD in the highest tertile compared with that in the lowest tertile was 7.39 (95% confidence interval; 1.71-31.91). There was no significant difference in median values of 8-iso-PGF2α between single- and multi-vessel CAD.
Conclusion: Urinary 8-iso-PGF 2α was independently associated with significant CAD in this case-control study.
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KEYWORD
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Oxidative stress, Coronary artery disease
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