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KMID : 0368120120420110747
Korean Circulation Journal
2012 Volume.42 No. 11 p.747 ~ p.752
Positive Vascular Remodeling in Culprit Coronary Lesion is Associated With Plaque Composition: An Intravascular Ultrasound-Virtual Histology Study
Lee Chung-Seop

Seo Young-Hoon
Yang Dong-Ju
Kim Ki-Hong
Park Hyun-Woong
Yuk Hyung-Bin
Lee Moo-Sik
Kim Wan-Ho
Kwon Taek-Geun
Bae Jang-Ho
Abstract
Background and Objectives: The relationship between the positive remodeling (PR) of a coronary artery and plaque composition has been studied only in a relatively small number of study population or non-culprit lesion. We evaluated the association between coronary plaque composition and coronary artery remodeling in a relatively large number of culprit lesions.

Subjects and Methods: The study population consisted of 325 consecutive patients with coronary artery disease that underwent intravascular ultrasound-virtual histology examination in a culprit lesion. The remodeling index (RI) was calculated as the lesion external elastic membrane (EEM) area divided by the average reference EEM area.

Results: The lesions with PR (RI>1.05, n=97, mean RI=1.19¡¾0.12) had a higher fibrous volume/lesion length (3.85¡¾2.12 mm3/mm vs. 3.04¡¾1.79 mm3/mm, p=0.003) and necrotic core volume/lesion length (1.26¡¾0.89 mm3/mm vs. 0.90¡¾0.66 mm3/mm, p=0.001) than those with negative remodeling (NR) (RI<0.95, n=132, mean RI=0.82¡¾0.09). At the minimal luminal area site, the lesions with PR had a higher fibrous area (5.81¡¾3.17 mm2 vs. 3.61¡¾2.30 mm2, p<0.001), dense calcified area (0.73¡¾0.69 mm2 vs. 0.46¡¾0.43 mm2, p=0.001), and necrotic core area (1.93¡¾1.33 mm2 vs. 1.06¡¾0.91 mm2, p<0.001) than those with NR. RI showed significant positive correlation with fibrous volume/lesion length (r=0.173, p=0.002), necrotic core volume/lesion length (r=0.188, p=0.001), fibrous area (r=0.347, p<0.001), fibrofatty area (r=0.111, p=0.036), dense calcified area (r=0.239, p<0.001), and necrotic core area (r=0.334, p<0.001). Multivariate analysis showed that the independent factor for PR was the necrotic core volume/lesion length (beta=0.130, 95% confidence interval; 0.002-0.056, p=0.037) over the entire lesion.

Conclusion: This study suggests that PR in a culprit lesion is associated with the necrotic core volume in the entire lesion, which is a characteristic of vulnerable plaque.
KEYWORD
Atherosclerosis, Coronary artery, Intravascular ultrasonography
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