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KMID : 0368120130430020087
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Korean Circulation Journal
2013 Volume.43 No. 2 p.87 ~ p.92
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The Prognostic Implication of Metabolic Syndrome in Patients with Heart Failure
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Yoon Hyun-Ju
Ahn Young-Keun
Kim Kye-Hun
Park Jong-Chun
Choi Dong-Ju
Han Seong-woo
Jeon Eun-Seok
Cho Myung-Chan
Kim Jae-Joong
Yoo Byung-Su
Shin Mi-Seung
Seong In-Whan
Kang Seok-Min
Kim Yung-Jo
Kim Hyung-Seop
Chae Shung-Chull
Oh Byung-Hee
Lee Myung-Mook
Ryu Kyu-Hyung
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Abstract
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Background/Objectives: Metabolic syndrome (MetS) increases the risk of heart failure (HF). The purpose of this study was to identify the prevalence of MetS in patients with HF and determine the syndrome’s association with HF in clinical and laboratory parameters.
Subjects and Methods: A total of 3200 HF patients (67.6±14.5 years) enrolled in a nationwide prospective Korea HF Registry between Jan. 2005 and Oct. 2009. Patients were divided into two groups according to the presence or absence of MetS at admission: group I (presence, n=1141) and group II (absence, n=2059).
Results: The prevalence of MetS was 35.7% across all subjects and was higher in females (56.0%). The levels of white blood cells, platelets, creatinine, glucose, and cholesterol were significantly higher in group I than in group II. Left ventricular dimension and volume was smaller and ejection fraction was higher in group I than in group II. An ischemic cause of HF was more frequent in group I. The rates of valvular and idiopathic cause were lower in group I than in group II. The rate of mortality was lower in group I than in group II (4.9% vs. 8.3%, p<0.001).
Conclusion: Despite the increased cardiovascular risks in MetS, MetS was found to be associated with decreased mortality in HF.
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KEYWORD
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Metabolic syndrome, Heart failure
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