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KMID : 0368120130430070481
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Korean Circulation Journal
2013 Volume.43 No. 7 p.481 ~ p.487
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Cardiac Rehabilitation Increases Exercise Capacity with a Reduction of Oxidative Stress
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Fukuda Taira
Kurano Miwa
Fukumura Kazuya
Yasuda Tomohiro
Iida Haruko
Morita Toshihiro
Nakajima Toshiaki
Yamamoto Yumiko
Takano Nami
Komuro Issei
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Abstract
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Background/Objectives: Reactive oxygen species (ROS) mediate various signaling pathways that underlie vascular inflammation in atherogenesis and cardiovascular diseases. Cardiac rehabilitation (CR) has a variety of multiple beneficial effects, including anti-inflammatory effects. The purpose of the present study was to investigate the effects of CR on ROS in patients with cardiovascular diseases.
Subjects and Methods: The serum level of derivatives of reactive oxidative metabolites, an index of oxidative stress, was measured in 100 patients with cardiovascular diseases before, and, subsequently, 3 and 6 months after, CR. A biological antioxidant potential (BAP) test was applied to assess the antioxidant power of the serum.
Results: The resting reactive oxidative metabolite levels decreased 3-6 months after CR {pre: 351±97 Carratelli unit (CARR U), 3 months: 329±77 CARR U, 6 months: 325±63 CARR U, all p<0.01} with the increase of the percentage of the predicted values of V?O2 peak and the percentage of the predicted values of V?O2 at the anaerobic threshold (V?O2 AT) and the decrease of the B-type natriuretic peptide (BNP). The BAP test and antioxidative/oxidative stress ratio increased 6 months after CR. The % changes of the antioxidative/oxidative stress ratio was positively correlated with the % changes of V?O2 AT, and negatively correlated with the % changes of the BNP.
Conclusion: These results suggest that intensive supervised CR significantly improved exercise capacity, which may be attributable to an adaptive response involving more efficient oxidative metabolites or the increased capacity of endogenous anti-oxidative systems in patients with cardiovascular diseases.
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KEYWORD
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Reactive oxygen species, Antioxidants, Exercise therapy, Oxygen consumption, Cardiovascular diseases
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