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KMID : 0368120130430080519
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Korean Circulation Journal
2013 Volume.43 No. 8 p.519 ~ p.526
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One-Year Clinical Outcomes among Patients with Metabolic Syndrome and Acute Myocardial Infarction
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Ji Mi-Seon
Jeong Myung-Ho
Ahn Young-Keun
Kim Young-Jo
Chae Shung-Chull
Hong Taek-Jong
Seong In-Whan
Chae Jei-Keon
Kim Chong-Jin
Cho Myeong-Chan
Rha Seung-Woon
Bae Jang-Ho
Seung Ki-Bae
Park Seung-Jung
Acute Myocardial Infarction Investigators
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Abstract
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Background/Objectives: Metabolic syndrome (MetS) is an important risk factor for cardiovascular disease. However, the clinical outcome of acute myocardial infarction (AMI) with MetS has not been well examined. The purpose of this study was to evaluate the clinical outcomes of AMI patients with MetS.
Subjects and Methods: We evaluated a total of 6352 AMI patients who had successful percutaneous coronary interventions and could be identified for MetS between 2005 and 2008 at 51 hospitals participating in the Korea Acute Myocardial Infarction Registry. They were divided into 2 groups according to the presence of MetS: the MetS group (n=2493, 39.2%) versus the Non-MetS group (n=3859, 60.8%). In addition, 4049 AMI patients with high levels of low density lipoprotein-cholesterol (LDL-C) (≥100 mg/dL) among them, were divided into the MetS group (n=1561, 38.6%) versus the Non-MetS group (n=2488, 61.4%).
Results: In the overall population, there was no significant difference in 12-month the major adverse cardiac events (MACE) rate between the 2 groups. However, the MetS group showed a significantly higher 12-month MACE rate in the high LDL-C population. Multivariate analysis showed that MetS was an independent prognostic factor for 12-month MACE {hazard ratio (HR) 1.607, 95% confidence interval (CI) 1.027 to 2.513, adjusted p=0.038} and for 12-month target vessel revascularization (HR 1.564, 95% CI 1.092 to 2.240, adjusted p=0.015) in the high LDL-C population.
Conclusion: MetS patients with AMI in the overall population showed no significant difference in 12-month clinical outcomes. However, in patients with higher LDL-C ≥100 mg/dL, they showed significantly worse clinical outcome than Non-MetS patients. Therefore, it is important to ascertain the presence of MetS in AMI patients, and more aggressive therapy should be strongly considered for AMI patient with MetS.
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KEYWORD
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Metabolic syndrome, Myocardial infarction, Low density lipoprotein-cholesterol
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