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KMID : 0368120130430120819
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Korean Circulation Journal
2013 Volume.43 No. 12 p.819 ~ p.824
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Do Different Arterial Stiffness Parameters Provide Similar Information in High-Risk Patients for Coronary Artery Disease?
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Kim Kyung-Min
Kim Jeong-Min
Kim Hyun-Sik
Lee Jun-Won
Kim Jang-Young
Youn Young-Jin
Ahn Sung-Gyun
Lee Seung-Hwan
Yoon Jung-Han
Yoo Byung-Su
Ko An-Na
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Abstract
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Background and Objectives: The aim of our study was to compare the values of brachial-ankle pulse wave velocity (baPWV) measured with two different non-invasive methods as predictors of coronary artery disease (CAD) in patients who had undergone coronary angiography.
Subjects and Methods: From 6373 patients who visited our laboratory for non-invasive procedures, we enrolled 965 consecutive patients undergoing coronary angiography. Data for baPWV and peripheral augmentation index (pAI) were recorded. CAD was defined as greater than 50% stenosis of a major epicardial artery in a coronary angiogram. In addition, the severity of CAD was classified as: none/minimal or 1-, 2-, or 3-vessel disease, based on previous or current angiographic findings.
Results: Among 965 subjects, the mean age was 63.7±11.6 years, and 58.2% were male. Compared with subjects without CAD disease, those with CAD showed higher values of baPWV (16.6±3.5 m/sec vs. 15.9±3.4 m/sec, p<0.001), and lower values of pAI (73.5±15.9% vs. 76.0±15.7%, p=0.01). When the severity of CAD was expressed as none/minimal or 1-, 2-, or 3-vessel disease, there was a significant association between the extent of CAD and baPWV (p<0.001). In univariate analysis, high PWV and low pAI were associated with an increased prevalence of CAD (p<0.001).
Conclusion: Increased baPWV and decreased pAI were associated with the presence of CAD in the elderly.
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KEYWORD
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Pulse wave velocity, Coronary artery disease, Arterial stiffness
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