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KMID : 0368120160460020147
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Korean Circulation Journal
2016 Volume.46 No. 2 p.147 ~ p.153
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Rosuvastatin Reduces Blood Viscosity in Patients with Acute Coronary Syndrome
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Jung Lae-Young
Lee Sang-Rok
Jung Jin-Mu
Kim Yi-Shik
Lee Sun-Hwa
Rhee Kyoung-Suk
Chae Jei-Keon
Lee Dong-Hwan
Kim Dal-Sik
Kim Won-Ho
Ko Jae-Ki
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Abstract
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Background and Objectives: Wall shear stress contributes to atherosclerosis progression and plaque rupture. There are limited studies for statin as a major contributing factor on whole blood viscosity (WBV) in patients with acute coronary syndrome (ACS). This study investigates the effect of statin on WBV in ACS patients.
Subjects and Methods: We prospectively enrolled 189 consecutive patients (mean age, 61.3±10.9 years; 132 males; ST-segment elevation myocardial infarction, n=52; non-ST-segment elevation myocardial infarction, n=84; unstable angina n=53). Patients were divided into two groups (group I: previous use of statins for at least 3 months, n=51; group II: statin-naive patients, n=138). Blood viscosities at shear rates of 1 s-1 (diastolic blood viscosity; DBV) and 300 s-1 (systolic blood viscosity; SBV) were measured at baseline and one month after statin treatment. Rosuvastatin was administered to patients after enrollment (mean daily dose, 16.2±4.9 mg).
Results: Baseline WBV was significantly higher in group II ([SBV: group I vs group II, 40.8±5.9 mP vs. 44.2±7.4 mP, p=0.003], [DBV: 262.2±67.8 mP vs. 296.9±76.0 mP, p=0.002]). WBV in group II was significantly lower one month after statin treatment ([SBV: 42.0±4.7 mP, p=0.012, DBV: 281.4±52.6 mP, p=0.044]). However, low-density lipoprotein cholesterol level was not associated with WBV in both baseline (SBV: R2=0.074, p=0.326; DBV: R2=0.073, p=0.337) and after one month follow up (SBV: R2=0.104, p=0.265; DBV: R2=0.112, p=0.232).
Conclusion: Previous statin medication is an important determinant in lowering WBV in patients with ACS. However, one month of rosuvastatin decreased WBV in statin-naive ACS patients.
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KEYWORD
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Blood viscosity, Rheology, Acute coronary syndrome, Rosuvastatin
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