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KMID : 0368120160460030402
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Korean Circulation Journal
2016 Volume.46 No. 3 p.402 ~ p.407
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Levosimendan Reduces Lung Injury in a Canine Model of Cardiopulmonary Bypass
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Feng Jun-Bo
Liu Hai-Yuan
Chen Jia-Yi
Wang Ji-Yuan
Liu Zhuang
Ge Sheng-Lin
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Abstract
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Background and Objectives: To explore the lung-protective effect of levosimendan (LS) during cardiopulmonary bypass in a canine model by determining the wet/dry weight (W/D) ratio of lung tissue, malonaldehyde (MDA) and superoxide dismutase (SOD) concentrations, and performing a histological evaluation.
Materials and Methods: Thirty-two canines were divided randomly into four groups and underwent a routine aortic cross-clamping cardiopulmonary bypass procedure for 1 h, followed by recovery for 2 h. Animals were handled as follows: group C (means control group), no special treatment after aortic cross clamping; group P (means pulmonary artery perfusion group), pulmonary artery perfusion with cold oxygenated blood after aortic cross clamping; group LSIV (means intravenous injection of LS group), intravenous injection of LS (65 μg/kg) before thoracotomy, and the rest of the procedure was identical to the control group; group LPS (means pulmonary perfusion with LS group), pulmonary perfusion with cold oxygenated blood combined with LS (65 μg/kg) after aortic cross clamping. Lung tissues were removed and subjected to evaluation of pathological alterations, W/D ratio and MDA and SOD concentrations.
Results: In group C, the W/D ratio and MDA concentration were higher, while the SOD concentrations were lower (p<0.05). Compared with groups P and LSIV, the MDA concentration was lower in group LPS, while that of SOD was higher (p<0.05); Light and electron microscopy indicated that LS intervention reduced impairment of lung tissues.
Conclusion: Our findings suggest that LS plays an important role in protecting lung tissues.
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KEYWORD
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Levosimendan, Cardiopulmonary bypass, Canine, protective effect
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