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KMID : 0368120160460040481
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Korean Circulation Journal
2016 Volume.46 No. 4 p.481 ~ p.489
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Effect of n-3 Polyunsaturated Fatty Acids on Regression of Coronary Atherosclerosis in Statin Treated Patients Undergoing Percutaneous Coronary Intervention
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Ahn Jin-hee
Park Seo-Kwang
Park Tae-Sik
Kim Jin-Hee
Yun Eun-Young
Kim Sang-Pil
Lee Hye-Won
Oh Jun-hyok
Choi Jung-Hyun
Cha Kwang-Soo
Hong Taek-Jong
Lee Han-Cheol
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Abstract
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Background and Objectives: Statins remain the mainstay of secondary coronary artery disease (CAD) prevention, but n-3 polyunsaturated fatty acids (ω-3 PUFA) display biological effects that may also reduce the risk of atherosclerosis and CAD. However, data on the possible antiatherosclerotic benefits of adding ω-3 PUFA to statin therapy are limited. This study aimed to investigate the potential additive effects of ω-3 PUFA on regression of atherosclerosis in CAD patients receiving statin therapy and stent implantation.
Subjects and Methods: Seventy-four CAD patients undergoing percutaneous coronary intervention (PCI) with stent implantation were enrolled, prescribed statins, and randomly assigned to two groups: n-3 group (ω-3 PUFA 3 g/day, n=38) or placebo group (placebo, n=36). All patients completed the study follow-up consisting of an intravascular ultrasound at baseline and at 12 months.
Results: There was no difference in the baseline characteristics and distribution of other medications. No significant differences were observed in primary endpoints, including changes in atheroma volume index (?12.65% vs. ?8.51%, p=0.768) and percent atheroma volume (?4.36% vs. ?9.98%, p=0.526), and in secondary endpoints including a change in neointimal volume index (7.84 vs. 4.94 mm3/mm, p=0.087).
Conclusion: ω-3 PUFA had no definite additional effect on the regression of coronary atherosclerosis when added to statin in CAD patients undergoing PCI.
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KEYWORD
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n-3 polyunsaturated fatty acids, Atherosclerosis, Coronary artery disease, Statin
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