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KMID : 0368120160460060768
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Korean Circulation Journal
2016 Volume.46 No. 6 p.768 ~ p.773
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Neutrophil Lymphocyte Ratio as a Predictor of Left Ventricular Apical Thrombus in Patients with Myocardial Infarction
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Ertem Ahmet Goktug
Ozcelik Filiz
Kasapkara Haci Ahmet
Koseoglu Cemal
Bastug Serdal
Ayhan Huseyin
Sari Cenk
Bayram Nihal Akar
Bilen Emine
Durmaz Tahir
Keles Telat
Bozkurt Engin
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Abstract
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Background and Objectives: In this study, we examined the role of inflammatory parameters in an apical mural thrombus with a reduced ejection fraction due to large anterior myocardial infarction (MI).
Subjects and Methods: A total of 103 patients who had suffered from heart failure, 45 of whom had left ventricular apical thrombus (AT) after a large anterior MI, were enrolled in the study. A detailed clinical history was taken of each participant, biochemical inflammatory markers, which were obtained during admission, were analyzed and an echocardiographical and angiographical evaluation of specific parameters were performed.
Results: There were no statistically significant differences in terms of age, gender, and history of hypertension, diabetes mellitus, and atrial fibrillation between both groups (p>0.05). Similarly there were no statistically significant differences in terms of biochemical and echocardiographic parameters (p>0.05). However, there were significant differences in terms of neutrophil lymphocyte ratio (p=0.032). After a multivariate regression analysis, neutrophil lymphocyte ratio (NLR) was an independent predictor of thrombus formation (β: 0.296, p=0.024). The NLR >2.74 had a 78% sensivity and 61% specifity in predicting thrombus in patients with a low left ventricular ejection fraction.
Conclusion: In this study, neutrophil lymphocyte ratios were significantly higher in patients with apical thrombus.
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KEYWORD
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Inflammation, Thrombus, Myocardial infarction
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