|
KMID : 0368120160460060827
|
|
Korean Circulation Journal
2016 Volume.46 No. 6 p.827 ~ p.833
|
|
|
Endocan and Non-Dipping Circadian Pattern in Newly Diagnosed Essential Hypertension
|
|
Cimen Tolga
Bilgin Murat
Akyel Ahmet
Felekoglu Mehmet Ali
Nallbani Ali
Ozdemir Seyda
Erden Gonul
Ozturk Alpaslan
Dogan Mehmet
Yeter Ekrem
|
|
|
Abstract
|
|
|
Background and Objectives: Non-dipper hypertension is frequently accompanied by endothelial dysfunction and activation. Previous studies suggested that endocan may be a novel endothelial dysfunction marker. This study aims to investigate the association between circadian blood pressure (BP) pattern and plasma endocan levels together with high-sensitivity C-reactive protein (hsCRP) in patients with newly diagnosed untreated hypertension.
Subjects and Methods: Twenty-four hour ambulatory blood pressure monitoring was recorded in 35 dipper, 35 non-dipper hypertensives and 35 healthy controls. Endocan levels were measured by enzyme-linked immunosorbent assay. Serum levels of hsCRP were also recorded.
Results: Despite similar daytime and 24-hour average BP values between dippers and non-dippers, statistically significant high nocturnal BP was accompanied by a non-dipping pattern (Systolic BP: 132±9 vs. 147±11 mmHg; Distolic BP: 80±7 vs. 91±9 mmHg, respectively, p<0.001 for both). Non-dipper patients demonstrated higher endocan levels compared to dippers and normotensives (367 (193-844) pg/mL, 254 (182-512) pg/mL and 237 (141-314) pg/ml, respectively, p<0.001). HsCRP levels were significantly higher in non-dippers than the other groups (p=0.013). In a multivariate logistic regression analysis, endocan (p=0.021) and hsCRP (p=0.044) were independently associated with a non-dipping pattern.
Conclusion: Elevated endocan levels were found in non-dipper groups. Endocan and hsCRP were found to be independently associated with a non-dipping pattern. We suggest that elevated levels of endocan in non-dipper hypertensive patients might be associated with a longer duration of exposure to high BP. These results point to the possible future role of endocan in selection of hypertensive patients at higher risk or target organ damage.
|
|
|
KEYWORD
|
|
|
Blood pressure monitoring, ambulatory, Hypertension, Dipping pattern, Endocan
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
   
|