KMID : 0368120180480010048
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Korean Circulation Journal 2018 Volume.48 No. 1 p.48 ~ p.58
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Clinical Characteristics of Korean Patients with Bicuspid Aortic Valve Who Underwent Aortic Valve Surgery
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Sun Byung-Joo
Jin Xin Song Jae-Kwan Lee Sah-Min Lee Ji-Hye Park Jun-Bean Lee Seung-Pyo Kim Dae-Hee Park Sung-Ji Kim Yong-Jin Cho Goo-Yeong Song Jong-Min Kang Duk-Hyun Sohn Dae-Won
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Abstract
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Background and Objectives: Clinical data for Korean patients with bicuspid aortic valve (BAV) that underwent aortic valve (AV) surgery are currently limited.
Methods: Data for 1,160 consecutive adult BAV patients who underwent AV surgery from 2000 to 2014 in 4 tertiary referral centers were retrospectively analyzed. A standard case report form was used for clinical and echocardiographic parameters.
Results: Mean age at the time of AV surgery was 59¡¾13 years. The most common cause of AV surgery was aortic stenosis (AS, 892 [77%]), followed by aortic regurgitation (AR, 199 [17%]), and infective endocarditis (69 [6%]). AS showed a skewed peak in the aged population and was the predominant cause of AV surgery (87%) in patients ¡Ã50 years of age, whereas AR (46%) and active infective endocarditis (19%) were more common in younger patients (p<0.001). Echocardiographic determination of the BAV phenotype revealed that fusion of the right coronary cusp (RCC) and left coronary cusp (LCC) was most common (622 [53%]), followed by fusion of RCC and non-coronary cusp (NCC) (313 [27%]), and fusion of LCC and NCC (42 [4%]); the BAV phenotype could not be determined in the remaining 183 patients (16%). Fusion of RCC and LCC was more commonly observed in patients with AR than in those with AS (74% vs. 49%; p<0.001).
Conclusion: BAV patients were characterized by distinct surgical indications according to their age. Possible associations between BAV phenotypes and surgical indications with potential impacts of ethnicity need to be tested in further studies.
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KEYWORD
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Bicuspid aortic valve, Heart valve diseases, Phenotype, Cardiac surgical procedures
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