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KMID : 0368120180480030217
Korean Circulation Journal
2018 Volume.48 No. 3 p.217 ~ p.226
Low Common Carotid Artery Systolic Occlusion Pressure and Symptomatic Carotid Artery Stenosis Are Associated with Development of Neurologic Intolerance during Proximal Protected Carotid Artery Stenting
Kwon Hee-Jin

Park Jae-Hyeong
Lee Jae-Hwan
Jeong Hye-Seon
Song Hee-Jung
Kim Jei
Kim Mi-Joo
Kwon In-Sun
Seong In-Whan
Abstract
Background and Objectives: Neurologic intolerance (NI) is defined as the occurrence of neurological symptoms during carotid artery stenting (CAS). Because NI is inevitable problem, it may be helpful to anticipate its occurrence. So, we studied factors associated with NI during proximal protected CAS.

Methods: We retrospectively analyzed all consecutive patients underwent proximal protected CAS from August 2012 to January 2017.

Results: We included total 123 patients (109 males, 72¡¾8 years old). The total procedure time was 43¡¾12 minutes, and mean occlusion time was 4.8¡¾1.2 minutes. We divided CAS patients into 2 groups according to presence of NI; neurologic tolerance (NT; n=74, 60%) and NI (n=49, 40%) groups. After the univariate analysis, symptomatic carotid artery stenosis (p=0.003), absence of anterior communicating artery (p=0.015) and low common carotid artery occlusion pressure (CCAOP, p<0.001) were associated with NI. After the multivariate analysis, NI was significantly associated with symptomatic carotid artery stenosis (odds ratio [OR], 5.549; p=0.014) and systolic CCAOP¡Â42 mmHg (OR, 6.461; p<0.001). In NI group, 43 patients (88%) recovered right after the balloon deflation and 2 patients were normalized within 2 hours. However, 1 had major stroke and 3 had minor strokes in 4 patients with persistent NI ¡Ã24 hours.

Conclusions: About 40% showed NI during the CAS. Most of them (88%, 43 of 49 patients) recovered after the balloon deflation, but stroke incidence was significantly higher in NI group. Symptomatic carotid artery stenosis and systolic CCAOP ¡Â42 mmHg were significantly associated with the development of NI during proximal protected CAS.
KEYWORD
Carotid stenosis, Stent, Neurologic symptoms, Embolic protection devices
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