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KMID : 0368120220520020110
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Korean Circulation Journal
2022 Volume.52 No. 2 p.110 ~ p.122
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Stem Cell and Exosome Therapy in Pulmonary Hypertension
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Oh Se-Yeon
Jung Ji-Hye
Ahn Kyung-Jin
Jang Albert Young-Woo
Byun Kyung-Hee
Yang Phillip C.
Chung Wook-Jin
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Abstract
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Pulmonary hypertension is a rare and progressive illness with a devastating prognosis. Promising research efforts have advanced the understanding and recognition of the pathobiology of pulmonary hypertension. Despite remarkable achievements in terms of improving the survival rate, reducing disease progression, and enhancing quality of life, pulmonary arterial hypertension (PAH) is not completely curable. Therefore, an effective treatment strategy is still needed. Recently, many studies of the underlying molecular mechanisms and technological developments have led to new approaches and paradigms for PAH treatment. Management based on stem cells and related paracrine effects, epigenetic drugs and gene therapies has yielded prospective results for PAH treatment in preclinical research. Further trials are ongoing to optimize these important insights into clinical circumstances.
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KEYWORD
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Stem cells, Exosomes, Pulmonary arterial hypertension, Right heart failure
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