Giant lymph node hyperplasia(Catleman's disease) is a rare disease, which represents a peculiar form of lymph node hyperplasia. Generally, it has been considered as benign and localized disease but recently, revealed malignant transformation in
some
cases of multicenteric form. It usually occurs on the mediastinum and occasionaly neck, lung, axilla mesentery, broad ligament, retroperitoneum or soft tissue of extremities. Histopathologically, it is divided into hyaline vascular or plasma cell
type
and the former is characterized with prominent vascular proliferation and hyalinization in the central portion and tight concenteric layering of lymphocytes at the periphery of the periphery of the fillicles (mantle zone) and the latter is
characterized
by a diffuse plasma cell proliferation in the interfollicular area. From the point of view of clinical presentation, it has been divided into solitary form, which occurs multiple location and has systemic manifestation and transformation into
malignancy.
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