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KMID : 0370920130300020083
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Yeungnam Univercity Journal of Medicine
2013 Volume.30 No. 2 p.83 ~ p.89
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Risk Factors of Nosocomial Bacteremia of Extended-spectrum β-Lactamase Producing Escherichia coli
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Ko Dai-Sik
Moon Song-Mi
Lee Ji-Sung
Park Yoon-Soo
Cho Yong-Kyun
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Abstract
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Background: The prevalence of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli is increasing rapidly worldwide. Treatment options for ESBL-producing E. coli are limited, and infections caused by this organism are associated with improper antibiotic use, a long hospital stay, and increased mortality. Thus, the assessment and early recognition of the risk factors of nosocomial infections due to ESBL-producing E. coli are important for the infection control and proper treatment.
Methods: A case-control study was performed that included nosocomial episodes of ESBL-producing E. coli bacteremia at a tertiary care hospital from January 2004 to December 2007. For each case patient, three controls were randomly selected and data on predisposing factors were collected.
Results: Fifty-five cases of nosocomial ESBL-producing E. coli bacteremia were studied. Carbapenem usage (OR: 11.3, 95% CI: 1.1-115.9, p=0.041), quinolone usage (OR: 4.5, 95% CI: 1.1-18.8, p=0.042), biliary obstructive disease (OR: 11.8, 95% CI: 3.0-46.7, p<0.001) and the APACHE II score (OR: 1.3, 95% CI: 1.2- 1.5, p<0.001) were analyzed as independent risk factors of nosocomial ESBL-producing E. coli bacteremia.
Conclusion: Our results showed that physicians caring for patients with risk factors of nosocomial bacteremia should consider ESBL-producing E. coli as the causative organisms of the disease.
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KEYWORD
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Extended-spectrum β-lactamase, Escherichia coli, Nosocomial, Bacteremia
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