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KMID : 0371420160900030179
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Annals of Surgical Treatment and Research
2016 Volume.90 No. 3 p.179 ~ p.182
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Acute hyperammonemic encephalopathy after 5-fluorouracil based chemotherapy
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Yi Hee-Jung
Hong Kyung-Sook
Moon Na-Ra
Chung Soon-Sup
Lee Ryung-Ah
Kim Kwang-Ho
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Abstract
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5-Fluorouracil (5-FU) based chemotherapy has been commonly used to treat metastatic or advanced colon cancer as an adjuvant chemotherapy. Although the side effects of 5-FU such as gastrointestinal problems and neutropenia and thrombocytopenia are common, not many cases of 5-FU related encephalopathy are reported. Hyperammonemic encephalopathy is a rare central nervous system toxicity following 5-FU chemotherapy manifesting as altered mental status with elevated ammonia levels with no radiologic abnormality. We report one case of 5-FU induced hyperammonemic encephalopathy occurring after Folfox4 (oxaliplatin, folinic acid and 5-fluorouracil) chemotherapy in a colon cancer patient who presented with confused mental status soon after the chemotherapy and review the 5-FU related encephalopathy.
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KEYWORD
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Colorectal neoplasma, 5-Fluorouracil, Hyperammonemia, Metabolic brain diseases
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