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KMID : 0371420170930060287
Annals of Surgical Treatment and Research
2017 Volume.93 No. 6 p.287 ~ p.292
Development of second primary cancer in Korean breast cancer survivors
Jung Hong-Kyu

Park Su-Yeon
Kim Nam-Won
Lee Jong-Eun
Kim Zi-Sun
Han Sun-Wook
Hur Sung-Mo
Kim Sung-Young
Lim Cheol-Wan
Lee Min-Hyuk
Lee Ji-Hyoun
Abstract
Purpose: Breast cancer survivors have slightly increased the risk of second primary cancers. Breast, colon, uterine, and ovarian cancers are common secondary cancers in breast cancer survivors. In this study, we assessed the development of second primary cancers of breast cancer survivors in Korea.

Methods: Medical records of patients with breast cancer in 3 tertiary medical institutions were reviewed retrospectively. We evaluated secondary malignancy diagnosed at least 2 months after the breast cancer diagnosis. Based on the International Classification of Disease-9 codes of malignancies, secondary primary breast cancer records were evaluated with person-year adjustment. The standardized incidence ratio (SIR) was assessed using national cancer incidence.

Results: A total of 3,444 treatment records were included from 3 medical centers. The cumulative incidence of overall second primary cancers was 2.8% (n = 93). The SIR was significantly higher in all sites (1.56; 95% confidence interval [CI], 1.26?1.91), endometrial cancer (5.65; 95% CI, 2.06?12.31), biliary tract cancer (3.96; 95% CI, 1.19?8.60), and thyroid cancer (2.29; 95% CI, 1.67?3.08).

Conclusion: The incidence of cancer was higher in breast cancer survivors compared to general population. Surveillance of secondary cancer in this group should be recommended individually considering the benefit related to the prognosis of primary breast cancer.
KEYWORD
Breast neoplasms, Neoplasms, Second primary, Survivors, Early detection of cancer
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