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KMID : 0371420221030040227
Annals of Surgical Treatment and Research
2022 Volume.103 No. 4 p.227 ~ p.234
Is the platelet function test effective in predicting blood loss in patients undergoing hepatic resection?
Gwon Jun-Gyo

Ko Sun-Young
Kim Hyo-Kee
Abstract
Purpose: The platelet function analyzer (PFA)-100/200 is widely used to assess platelet function. However, its role in predicting the perioperative risk of bleeding in patients undergoing liver resection remains controversial. Therefore, we aimed to ascertain whether the platelet function test could be useful in predicting bleeding risk in patients undergoing hepatic surgery.

Methods: The study participants were patients who underwent hepatectomy for hepatocellular carcinoma at our hospital over a period of 10 years from January 1, 2010 to May 31, 2020. PFA-200 values of these patients were divided into 2 groups; normal (n = 333) and prolonged (n = 39).

Results: There were no significant differences regarding the volumes of calculated blood loss during surgery between the normal and prolonged PFA groups (879.55 ¡¾ 1,046.50 mL vs. 819.74 ¡¾ 912.64 mL, respectively; P = 0.733); intraoperative RBC transfusion (0.52 ¡¾ 2.02 units vs. 0.26 ¡¾ 1.02 units, P = 0.419) and postoperative RBC transfusion (0.24 ¡¾ 1.17 units vs. 0.46 ¡¾ 1.97 units, P = 0.306) were similar between the 2 groups, respectively. Multivariate analysis revealed no association between PFA closure time and calculated blood loss (hazard ratio, 1.06; P = 0.881). Moreover, there was no association between PFA closure time and preoperative laboratory results or assessment of tool-related liver function in multivariate analysis.

Conclusion: There was no correlation between the amount of blood loss and platelet function in patients who underwent liver resection. In patients undergoing liver resection who are not managed on antiplatelet agents or do not have chronic kidney disease, the use of routine PFA is not recommended.
KEYWORD
Bleeding, Hepatectomy, Liver, Platelet function tests
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