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KMID : 0374019790020040205
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Ewha Medical Journal
1979 Volume.2 No. 4 p.205 ~ p.210
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Effect of Long-term Mega Vitamin C Ingestion on the Blood Ascorbic acid Concentration in Man
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Abstract
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Daily 1 gm of ascorbic acid was administered to 5 healthy adult volunteers who had not been taking any vitamin preperations for at -least 2 months prior to present study. Periodical determination of plasma and RBC ascorbic acid concentrations were carried out throughout 9 weeks of adminstration and1after cessation of ascorbic acid.
Mean baseline (0 day) ascorbic acid concentrations were low normal (4.416f1.03ug/ - ml) in plasma and 4.05f1.14ug/l01RBC. PIasma concentrations were raised and remained higher throughout 9 weeks and slowly returned to baseline level after cessation of ingestion.
According to baseline plasma ascorbic acid concentrations ~ and responses to vitaaminC_administrations, subjects were divided into suboptimal (1.552.4ug/ml) and normal (68ug/ml) group. After rise of concentrations in RBC, there was decreasing tendency in spite of continous ingestion of ascorbic acid. Blood concentrations of suboptimal group responded more rapidly and in greater rates than that of normal group. At 7 weeks RBC concentrations of normal group were decreased below baseline and did not return to baseline until 2 weeks after cessation of ascorbic acid ingestion. Therefore it is concluded that routine or habitual long-term ingestion of Mega Vita-min C is not desirable. Whenever it is necessary, intermittent. short terns therapy is highly recommended to prevent rebound lowering and hypoascorbicacidetnia after cessation of therapy.
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