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KMID : 0376219650020010071
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Chonnam Medical Journal
1965 Volume.2 No. 1 p.71 ~ p.80
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The Rabbit Blood Pressure Response to Guanethidine
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Abstract
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It was shown in the cat and dog that an intravenous guanethidine caused a marked elevation of blood pressure by releasing endogenous catecholamines. The rabbit blood pressure, however, was shown to be abruptly lowered by an intravenous guanethidine. In this study the author attempted to observe the guanethidine effects on the rabbit blood pressure in more detail. The results were as follows:
1) In urethane- or non-anesthetized rabbit an intravenous guanethidine(1-5 mg/kg) elicited a marked abrupt fall which was followed by sustained hyfotension. The hypotensive state was gradually restored, and 60 to 100mmHg of the pressure was attained in about 60 minutes. The second and successive doses of guanethidine, given at intervals of 30~60 minutes, elicited only a transient abrupt fall.
2) Treatment of rabbits with guanethidine (5 mg/kg, i. v.) about 15 hours previously changed the responses to the second or third dose of guanethidine, that is, elevation of the blood pressure was elicited.
3) Rabbits chronically treated with guanethidine (6 successive days, 5mg/kg, subcutaneously) showed only a transient abrupt fall to the first dose of intravenous guanethidine which was not followed by the sustulned hypotension.
4) Rabbits treated with JB-516 (10 mg/kg) reacted with elevation of the pressure to guanethidine.
5) Cord-sectioned rabbits showed pressor response to guanethidine, though weak .6) Guanethidine potentiated the pressor effect of tyrarmine, which is known to act by releasing endogenous catecholamines, as well as that of epinephrine.
In cord-sectioned rabbits, however, the tyramine effect was reduced and the epinephrine effort 11·as not poteiltiated.
From tlle above data, the mechanisms that an intravenous guailethidine rabbits could not cause elvation of the blood pressure were discussed.
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