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KMID : 0376219930300010083
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Chonnam Medical Journal
1993 Volume.30 No. 1 p.83 ~ p.91
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6-Ketoprostaglandin F_(12) and Thromboxane B₂ Concentrations of Maternal Blood in Pregnancy Induced Hypertension
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Abstract
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Pathogenesis of pregnancy-induced hypertension is still controversial. The purpose of this study is to investigate pathophysiologic correlation between prostanoid con￢centration in maternal blood and pregnancy-induced hypertension. This study was performed on 47 pregnant patients associated with pregnancy-induced hypertension and 17 normal pregnant women seen in Chonnam University Hospital in KwangJu.
In this study, the blood concentrations of 6-ketoprostaglandin F1α and throm￢boxane B 2were measured by radioimmunoassay.
1. The mean maternal blood concentration of 6-ketoprostglandin F1α in pregnancy￢ induced hypertension group was 444±42pg /ml, which was not significantly dif￢ferent from the concentration of normotensive group(452±54pg /ml ).
2. The mean maternal blood concentration of thromboxane B2 in pregnancy ￢induced hypertension group was 560±40pg /ml, which was significantly higher than the concentration of normotensive group(345±31pg/ml)(P<0.05). But there was no difference between mild group and severe group.
3. There was no significant difference in thromboxane B2 to 6-keto prostaglandin F1 ratio between pregnancy-induced hypertension group(1.91±0.22) and normo￢tensive group(1.14±0.26).
The ratio also was not different between mild and severe pregnancy-induced hypertension.
These result suggest that the changes in the serum levels of prostaglandins are not the cause but the result of pregnancy-induced hypertension.
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KEYWORD
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