KMID : 0379519930090020225
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Çѱ¹µ¶¼ºÇÐȸÁö 1993 Volume.9 No. 2 p.225 ~ p.232
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Lee Yong-Soon
Kang Kyung-Sun Seo Kwang-Won Nam Ki-Hoan Cho Jae-Jin
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Abstract
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SCi-B-Vac, the 3rd hepatitis B vaccine , was selected for clinical evaluation on the basis of toxicologic profiles in preclinical studies. These studies were performed to obtain information on its toxic signs, organs which are mainly affected, and to estimate its lethality in mice and rats given Sci-B-Vac through two routes of administratin. In male and female rats given a single intragastrical dose of Sci-B-Vac, we estimated that LD_{50} values were over 2.00 ml/100g B.W. (10ng/ml), respectively.
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KEYWORD
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Sci-B-Vac, Hepatitis B Vaccine, LD_{50}, Rat, Mice
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