KMID : 0379519990150030313
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Çѱ¹µ¶¼ºÇÐȸÁö 1999 Volume.15 No. 3 p.313 ~ p.321
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Curcumin¾Ö ÀÇÇØ À¯µµµÈ egr-1 ¹× c-myc À¯ÀüÀÚ¿¡ ÀÇÇÑ ¹ßÇö °¨¼Ò°¡ CpG oligodeoxynucleotide·Î ÃËÁøµÈ ¹Ì¼º¼÷ B ¸²ÇÁÁ¾ BKS-2ÀÇ ¼ºÀå Áõ°¡ ¾ïÁ¦
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Han Seong-Su
Chung Seung-Tae
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Abstract
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To investigate the role of egr-1 and c-myc in immature murine B cell lymphoma BKS-2, we treated BKS-2 with curcumin and(or) CpG oligodeoxynucleotide(ODN). CpG ODN increased proliferation of BKS-2 cells up to 170% at 10 ¥ìM. The mRNA levels of egr-1 and c-myc were dramatically upregulated as early as 30 min following stimulation and decreased eventually with the 1 ¥ìM of CpG ODN. c-myc mRNA level was increased and peaked at 3 h. Curcumin treatment caused growth arrest of BKS-2 by dose-dependent manner and dramatically downregulated the expression of egr-1 and c-myc after 0.5 h until 6 h. Moreover, BKS-2 cells were growth arrested from CpG ODN mediated proliferation by the treatment with curcumin. 50 ¥ìM of curcumin treatment suppressed the expression of egr-1 and c-myc upregulated by CpG ODN. In summary. Curcumin caused the growth arrest of BKS-2 immature B-cell lymphoma and also inhibited the proliferation effect of CpG ODN to BKS-2 via downregulation of egr-1 and c-myc.
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KEYWORD
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Curcumin, CpG ODN, immature B cell lymphoma, egr-1, c-myc
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