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KMID : 0379520010170000219
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2001 Volume.17 No. 0 p.219 ~ p.225
An Examination of Variation in Risk Assessment Practices in Relation to Assessors¡¯ Goals: American and International Practices
Lorenz R. Rhomberg

Abstract
The basic structure for assessment of potential health risks from environmental chemicals is widely agreed upon, but many of the details of risk assessment procedures differ among practitioners. Government regulatory agencies typically have guidelines or standard procedures for their risk assessments, established to ensure consistency and comparability, to set standards for adequacy, and to embody underlying tenets. In setting and updating such guidelines, each agency takes into account not only the prevailing thinking about appropriate procedures, but also its own goals and responsibilities and the precedents it has set for itself in past analyses. This results in variations in methods, and consequently in characterization of risks, among regulatory assessments, even when they are based on the same data. As a result, adopting existing assessments from a variety of regulatory bodies needs to be done with caution. This paper examines some of the variants in risk assessment approaches among American federal regulatory agencies and relates them to the variations in regulatory responsibilities of those groups. Comparisons to international practices are also drawn. The impact on development of world-wide risk standards is discussed.
KEYWORD
Risk Assessment Methodology, Harmonization, Non-Tariff Trade Barriers, Weight of Evidence, Carcinogenic Potency, Acceptable Daily Intake
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