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KMID : 0379520020180020139
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한국독성학회지
2002 Volume.18 No. 2 p.139 ~ p.147
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Subcutaneous Toxicity Evaluation of a Combination Vaccine against Hantaan and Puumala Viruses in Rats for 4 Weeks
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Lee Su-Hae
Jung Eun-Yong
No Kyong-Ok
Sin Ji-Soon
Ahn Chang-Nam
Kim Dae-Joong
Nam Sang-Yoon
Kang Jong-Koo
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Abstract
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Hantaan (HTNV) and Puumala (PUUV) viruses cause hemorrhagic fever with renal syndrome in human. In the present study, the repeated dose toxicity of the HTNV-PUUV combination vaccine was evaluated in Sprague-Dawley rats. Animals were injected subcutaneously for 28 days with dosages of 0, 0.017, 0.17 and 1.7 dose/kg body weight per day, respectively. No any significant changes of body weight, food and water consumptions were shown. There were no death and clinical findings during the experimental period. In both male and female rats, there were not significant changes in hematological and serum biochemical analysis, urinalysis, and ophthalmoscopic and histopathological examination. These results indicate that the HTNV-PUUV combination vaccine may have no toxic effects and no observed adverse effect level (NOAEL) may be over 1.7 dose/kg/day at subcutaneous route in rats.
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KEYWORD
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Repeated dose toxicity, HTNV-PUUV combination vaccine, Rats
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