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KMID : 0379520020180020195
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한국독성학회지
2002 Volume.18 No. 2 p.195 ~ p.203
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Single and Four-Week Intravenous Toxicity Studies of a Novel Cephalosporin Antibiotic Agent, IDC-7181, in Rats
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Zhang Hu-Song
Huang Zai-Zhi
Shin Jang-Woo
Jung Eun-Yong
Sin Ji-Soon
Lee Su-Hae
Lee Jong-Sung
Kang Jae-Hoon
Kim Kee-Won
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Abstract
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This study was performed to evaluate single and repeated-dose toxicities oj a new cophalosporin antibiotic agent IDC-7l81 in Sprague-Dawley rats. IDC-7181 was injected intravenously to rats at dose levels of 0, 3.2, 16, 80, 400 and 2,000 mg/kg/day for single-dose toxicity study and at dose levels of 0, 10, 50 and 250 mg/kg/day for 4-week repeated-dose toxicity study. In both studies, there were no dose-related changes in mortality clinical signs, body weight changes, food and water consumption, opthalmoscopy, organ weights, urine analysis, biochemical examination, and hematological findings of all animals treated with IDC-7l8l. Gross and histopathological findings revealed no evidence of specific toxicity related to IDC-7181. These results suggest that the intravenous maximum tolerated dose value of IDC-7181 may be over 250 mg/kg and LD_{50} value may be over 2,000 mg/kg in rats.
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KEYWORD
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Single and repeated-dose toxicity, IDC-7181, Cephalosporin, Rats
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