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KMID : 0379520020180030233
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한국독성학회지
2002 Volume.18 No. 3 p.233 ~ p.240
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Haplotype Distribution of the beta_2-Adrenergic Receptor Gene in Korean Essential Hypertensives
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Bae Joon-Seol
Kang Byung-Yong
Lee Kang-Oh
Yoon Tae-Joong
Kim Jae-Hyoun
Kim Ki-Tae
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Abstract
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In view of the effect of beta_2-Adrenergic receptors (beta_2-AR) as a risk factor for essential hypertension, we investigated the Fnu4HI and MnlI RFLPs of beta_2 -AR gene in the Korean patients with essential hypertension and normal controls. There were no significant differences in the allele and genotype of these polymorphisms between normotensive and essential hypertensive subjects. In ethnic comparison, the allele frequencies of these three sites contained Nde I RFLP reported the association with essential hypertension in Korean population previously, were very different from those of other ethnic populations studied. The significant linkage disequilibrium was detected only in hypertensive group between Nde I and Fnu4HI sites. The Fnu4HI RFLP was also significantly associated with plasma triglyceride (TG) level. Therefore, our results suggest that the significant association between Fnu4HI variation in the human beta_2-AR gene and plasma TG level may reflect the potential role of human beta_2-AR gene as one of the genetic components for cardiovascular risk.
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KEYWORD
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beta_2-adrenergic receptor, Essential hypertension, Haplotype, Polymorphism
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