|
KMID : 0379520070230010073
|
|
한국독성학회지
2007 Volume.23 No. 1 p.73 ~ p.78
|
|
|
Genotoxicity Study of Magnolia obovata Extracts
|
|
Lee Seung-Ho
Ryu Jae-Myun
Seo Im-Kwon
Lee Tae-Hee
Kim Yun-Bae
Moon Sung-Kwon
Jung Kyung-Hwan
Park Kee-Rang
Hwang Seock-Yeon
|
|
|
Abstract
|
|
|
|
To evaluate the immuno-toxicity of magnolia extracts, mutagenicity of Salmonella, chromosome aberration of Chinese hamster ovary (CHO) cells and micronucleus formation in rats were examined. Magnolia extracts at the concentrations of 312{sim}5,000{mu}g/plate did not induce mutagenicity in Salmonella typhimurium TA 98, TA 100 and TA 1535 with and without metabolic activation of S-9 mixture. In chromosome aberration assay, Magnolia extracts at the concentrations of 50{sim}800{mu}g/plate did not cause a significant chromosome aberration in CHO cells with and without metabolic activation of S-9 mixture. Magnolia extracts were treated with dose of 0.5, 1 and 2 g/kg in ICR mice. After 48 hours, the frequencies of the micro-nucleided polychromasia erythrocytes (MNPCE) were determined in bone marrows isolated from the mice. Magnolia extracts did not increase the incidence of polychromasia erythrocytes of bone marrow in ICR mice. These results show that Mgnolia extracts did not induce any harmful genotoxic effects
|
|
|
KEYWORD
|
|
|
Magnolia extracts, Mutagenicity, Chromosome aberration assay, Micronucleus formation, Micro-nucleided polychromasia erythrocytes
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
 
|