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KMID : 0379520070230010079
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한국독성학회지
2007 Volume.23 No. 1 p.79 ~ p.86
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Single & 14-Day Repeated Oral Toxicity Study and Genotoxicological Safety Estimate of Plantamajoside Isolated from Plantago asiatica
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Park Byung-Gyu
Lee Hyun-Sun
Jung Sung-Hoon
Koo Yun-Chang
Hong Chung-Oui
Lee Sun-Joo
Lee Kwang-Won
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Abstract
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The isolated plantamajoside from Plantago asiatica that is often used as a marker compound in chemotaxonomic studies has various bioactivites such as the inhibitions of cyclic AMP phosphodi-esterase and 5-lipoxygenase, microbial growth and inflammation, and currently demands the generation of toxicity data. The purpose of this study was to examine the toxicities of the single and 14 days repeated dose toxicity in Sprague-Dawley rats orally administrated with plantamajoside at dose levels of 0, 500, 1000, and 2000 mg of dried material/kg body weight/day. The results showed that there was no difference in body weight change, food intake, water consumption, or relative organ weight among different dose groups. Also we observed no death and abnormal clinical signs were observed during the experimental period. Between the groups orally administered Plantago asiatica and the control group, there was no statistical significance in hematological test or serum biochemical values. There were no gross findings at final sacrifice. There was no evidence of histopathological alteration mediated by 14 days treatment with Plantago asiatica. These results suggest that no observed adverse effect level (NOAEL) of the oral application was considered to be more than 2000 mg/kg in rats under the conditions employed in this study. Another observation was performed to investigate the safety of Plantago asiatica in respect of genotoxicity. This substance was examined that Salmonella typhimurium reversion assay (Ames test) in strain TA98, TA100, TA1535. In the reverse mutation test, Plantago asiatica did not induce mutagenicity in Samonella typhimurium with and without metabolic activation. These results indicated that Plantago asiatica had no genotoxicity.
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KEYWORD
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Plantago asiatica, plantamajoside, single and repeated-dose toxicity, ames test, NOAEL
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