Àá½Ã¸¸ ±â´Ù·Á ÁÖ¼¼¿ä. ·ÎµùÁßÀÔ´Ï´Ù.
KMID : 0379520070230030271
Çѱ¹µ¶¼ºÇÐȸÁö
2007 Volume.23 No. 3 p.271 ~ p.278
Tumorigenesis Study of Canine Adipose Derived-mesenchymal Stem Cell
Lee Eun-Sun

Kwon Eun-A
Park Jung-Ran
Kang Byeong-Cheol
Kang Kyung-Sun
Cho Myung-Haeng
Abstract
Several recent studies demonstrated the potential of bioengineering using stem cells in regenerative medicine. Adult mesenchymal stem cells (MSCs) have the pluripotency to differentiate into cells of mesodermal origin, i.e., bone, cartilage, adipose, and muscle cells; they, therefore, have many potential clinical applications. On the other hand, stem cells possess a self-renewal capability similar to cancer cells. For safety evaluation of MSCs, in this study, we tested tumorigenecity of canine adipose derived mesenchymal stem cells (cAD-MSCs) using Balb/c-nu mice. In this study, there were no changes in mortality, clinical signs, body weights and biochemical parameters of all animals treated. In addition, there were no significant changes between control and treated groups in autopsy findings. These results indicate that cAD-MSC has no tumorigenic potential under the condition in this study.
KEYWORD
Canine adipose derived mesenchymal stem cells, BALB/c nu mice, Tumorigenicy
FullTexts / Linksout information
 
Listed journal information
ÇмúÁøÈïÀç´Ü(KCI) KoreaMed