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KMID : 0379520070230040341
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한국독성학회지
2007 Volume.23 No. 4 p.341 ~ p.345
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The Correlativity of Lipopolysaccharide and Houttuynia cordata Thunb Mixture Extract to Lipid Metabolism
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Kwon Ryun-Hee
Kang Kum-Suk
Kim In-Deok
Ha Bae-Jin
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Abstract
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This study was designed to investige the effects of Houttuynia cordata Thunb mixture extract on the lipid metabolism in the lipopolysaccharide (LPS)-induced liver damage of rats. LPS-treatment increased the levels of total-lipid, LDH (lactate, dehydrogenas), triglyceride (TG) and malondialdehyde (MDA). But Houttuynia cordata Thunb mixture extract (HM) pretreatment decreased the levels of total lipid, LDLcholesterol, TG and MDA. Also LPS-treatment decreased total cholesterol and HDL-cholesterol, but HM-pretreatment increased both of them. These results demonstrated that HM-pretreatment had the preventive effects against the dyfunction of lipid metabolism in the LPS-induced liver damage of rats.
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KEYWORD
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Lipopolysaccharide, MDA, HDL, Houttuynia cordata Thunb
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