KMID : 0379520080240030183
|
|
Çѱ¹µ¶¼ºÇÐȸÁö 2008 Volume.24 No. 3 p.183 ~ p.188
|
|
Strain-dependent Differences of Locomotor Activity and Hippocampus-dependent Learning and Memory in Mice
|
|
Kim Joong-Sun
Kim Seong-Ho Kim Jong-Choon Lee Yong-Duk Shin Tae-Kyun Kim Seung-Joon Moon Chang-Jong Yang Mi-Young Son Yeong-Hoon
|
|
Abstract
|
|
|
The behavioral phenotypes of out-bred ICR mice were compared with those of in-bred C57BL/6 and BALB/c mice. In particular, this study examined the locomotor activity and two forms of hippocampus-dependent learning paradigms, passive avoidance and object recognition memory. The basal open-field activity of the ICR strain was greater than that of the C57BL/6 and BALB/c strains. In the passive avoidance task, all the mice showed a significant increase in the cross-over latency when tested 24 hours after training. The strength of memory retention in the ICR mice was relatively weak and measurable, as indicated by the shorter cross-over latency than the C57BL/6 and BALB/c mice. In the object recognition memory test, all strains had a significant preference for the novel object during testing. The index for the preference of a novel object was lower for the ICR and BALB/c mice. Nevertheless, the variance and the standard deviation in these strains were comparable. Overall, these results confirm the strain differences on locomotor activity and hippocampus-dependent learning and memory in mice.
|
|
KEYWORD
|
|
Behavioral difference, Mouse strain, Locomotor activity, Passive avoidance, Object recognition memory
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|