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KMID : 0379520120280030139
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2012 Volume.28 No. 3 p.139 ~ p.141
A Transfer of Silver Nanoparticles from Pregnant Rat to Offspring
Lee Yeon-jin

Choi Jong-Hye
Kim Pil-Je
Choi Kyung-Hee
Kim Su-hyon
Shon Woo-chan
Park Kwang-Sik
Abstract
Silver nanoparticles (size: 7.9 ¡¾ 0.95 nm, dosage: 250 mg/kg) were orally administered to pregnant rats. At 4 days after parturition, four pups were randomly selected (one pup from one dam) and silver level in liver, kidney, lung and brain was determined by ICP-MS and electron microscope. As results, silver nanoparticles highly accumulated in the tissues of the pups. Silver level in the treated group was 132.4 ¡¾ 43.9 ng/g in the kidney (12.3 fold compared to control group), 37.3 ¡¾ 11.3 ng/g in the liver (7.9 fold), 42.0 ¡¾ 8.6 ng/g in the lung (5.9 fold), and 31.1 ¡¾ 4.3 ng/g in the brain (5.4 fold). This result suggested that the possible transfer of silver nanoparticles from pregnant dams to the fetus through mainly placenta.
KEYWORD
Silver nanoparticles, Pregnant rats, Placenta transfer, Accumulation in pups
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