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KMID : 0379520120280040263
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한국독성학회지
2012 Volume.28 No. 4 p.263 ~ p.268
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Single-Dose Oral Toxicity of Fermented Scutellariae Radix Extract in Rats and Dogs
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Kim Myoung-Seok
Ham Seoung-Ho
Kim Jun-Ho
Shin Ji-Eun
Oh Jin
Kim Tae-Won
Yun Hyo-In
Lim Jong-Hwan
Jang Beom-Su
Cho Jung-Hee
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Abstract
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The aim of this study was to investigate the acute oral toxicity of fermented Scutellariae Radix (JKTMHGu- 100) in rats and dogs. JKTM-HGu-100 was orally administered at a dose of 2,000 mg/kg in Sprague-Dawley rats. An escalating single-dose oral toxicity test in beagle dogs was performed at doses of 500, 1000, and 2000 mg/kg with 4-day intervals. Clinical signs, changes in body weight, mortality, and necropsy findings were examined for 2 weeks following oral administration. No toxicological changes related to the test substance nor mortality was observed after administration of a single oral dose of JKTM-HGu-100 in rats or dogs. Therefore, the approximate lethal dose (LD) for oral administration of JKTMHGu-100 in rats was considered to be over 2,000 mg/kg, and the maximum tolerance doses (MTDs) in rats and dogs were also estimated to be over 2,000 mg/kg. These results indicate that JKTM-HGu-100 shows no toxicity in rodents or non-rodents at doses of 2,000 mg/kg or less.
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KEYWORD
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Scutellariae Radix, Single oral toxicity, Rat, Dog
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