Àá½Ã¸¸ ±â´Ù·Á ÁÖ¼¼¿ä. ·ÎµùÁßÀÔ´Ï´Ù.
KMID : 0379520140300040221
Çѱ¹µ¶¼ºÇÐȸÁö
2014 Volume.30 No. 4 p.221 ~ p.234
A Panoramic Overview of Mitochondria and Mitochondrial Redox Biology
Kim Ae-kyong

Abstract
Mitochondria dysfunction was first described in the 1960s. However, the extent and mechanisms of mitochondria dysfunction¡¯s role in cellular physiology and pathology has only recently begun to be appreciated. To adequately evaluate mitochondria-mediated toxicity, it is not only necessary to understand mitochondria biology, but discerning mitochondrial redox biology is also essential. The latter is intricately tied to mitochondrial bioenergetics. Mitochondrial free radicals, antioxidants, and antioxidant enzymes are players in mitochondrial redox biology. This review will provide an across-the-board, albeit not in-depth, overview of mitochondria biology and mitochondrial redox biology. With accumulating knowledge on mitochondria biology and mitochondrial redox biology, we may devise experimental methods with adequate sensitivity and specificity to evaluate mitochondrial toxicity, especially in vivo in living organisms, in the near future.
KEYWORD
Mitochondria, Redox, Free radical, Antioxidant, Antioxidant enzyme, Toxicology, Bioenergetics
FullTexts / Linksout information
 
Listed journal information
ÇмúÁøÈïÀç´Ü(KCI) KoreaMed