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KMID : 0380620100420060755
Korean Journal of Food Science and Technology
2010 Volume.42 No. 6 p.755 ~ p.761
Anti-cancer and Anti-inflammatory Effects of Mung Bean and Soybean Extracts
Imm Jee-Young

Kim Seok-Joong
Abstract
The quinone reductase (QR) inducing activities of mung bean and soybean solvent extracts were compared using murine hepatoma cells (Hepa 1c1c7). The mung bean extracts (ethylacetate and ethanol) showed higher chemoprevention index values (7.88-8.22) than those of soybean extracts (2.9-5.2) from four different cultivars. The mung bean extracts also had significantly higher inhibitory effects (47-62% at 100 ¥ìg/mL) than the soybean extracts (15-42% at 100 ¥ìg/mL) against the production of nitric oxide and prostaglandin E2 in lipopolysccharide stimulated macrophage RAW264.7 cells without cytotoxicity. Among seven recovered fractions of mung bean ethanol extract obtained by C 18 silica flash column chromatography, the most non-polar fraction exhibited the highest chemoprevention index of 10.4.
KEYWORD
mung bean extract, quinone reductase, nitric oxide, prostaglandin E2, cytotoxicity
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