|
KMID : 0380620160480060582
|
|
Korean Journal of Food Science and Technology
2016 Volume.48 No. 6 p.582 ~ p.589
|
|
|
Synergistic effects of grape branch and Pleurotus eryngii extract combination against inflammation on activated mast cells and atopic dermatitis-like skin lesions in mice
|
|
Yin Hong-Hua
Cho Byoung-Ok
Lee Hye-Seung
Chu Jung-Im
Jang Seon-Il
|
|
|
Abstract
|
|
|
|
The aim of this study was to investigate the synergistic anti-inflammatory and anti-dermatitis effects of grape branch extract (GBE) and Pleurotus eryngii (PEE) combinations on the active immune cells and atopic dermatitis-like skin lesions in mice. The results showed that the combination of GBE (12.5 μg/mL) and PEE (500 μg/mL) led to much stronger inhibitory effects on the production of inflammatory mediators, such as NO and PGE2 than that exhibited by GBE (25 μg/mL) and PEE (1000 μg/mL) alone, even at higher concentrations, in LPS-stimulated RAW 264.7 macrophages. The combination of GBE and PEE synergistically inhibited the production of TNF- and IL-6 in LPS-stimulated RAW 264.7 macrophages and PMA plus A23187-activated HMC-1 cells. Furthermore, combined GBE and PEE had a stronger ameliorative effect than GBE and PEE alone by inhibiting the clinical sores, IgE, and IL-4 on atopic dermatitis-like skin lesions in mice. Collectively, these results suggested that the combination of GBE and PEE produced a synergistic antiinflammatory and anti-atopic dermatitis effect on immune cells and atopic dermatitis-like skin lesions in mice.
|
|
|
KEYWORD
|
|
|
grape branch, Pleurotus eryngii, anti-inflammation, anti-atopic dermatitis, synergistic effect
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|