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KMID : 0385019920080020199
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Korean Journal of Laboratory Animal Science
1992 Volume.8 No. 2 p.199 ~ p.206
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HIstogenesis of Tumors Induced byf Chemicals:Glandular Stomach(pars glandularis)
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Abstract
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Gastric cancer is the most common malignant neoplasm among Koreans and Japans. The appearance of pyloric gland-type cells with a low pepsinogen isozyme 1 (Pg 1) content in the stomach carcinogenesis was examined by a combination of paradoxical concanavalin A (Con A) staining and immunohistochemical staining for Pg 1. Class III mucins and Pg 1 have been used as markers of phenotypic expression of cells of the pyloric gland cell type in tumors. The appearance of pyloric glands with a low Pg 1 content detected immunohistochemically may be considered to be a preneoplastic change preceding of the appearance of histologically changed mucosa. Adenomatous hyperplasia, which is considered to be a neoplastic change, showed almost the same degree of phenotyptic deviation of cells as that in adenocarcinomas and will develop into adenocarcinomas. Tntestinal metaplasia and intestinal-type cells in gastric carcinomas in the human stomach might also be independent phenomena. Rather than intestinal metaplasia, pyloric glands with changes of pepsinogen isozymes in human and rats gastric mucosa might be considered to indicate preneoplastic changes in human and rats gastric carcinogenesis. A suitable duration of testing, particularly for the second stage; is of pivotal importance in considering the design of an in vivo test protocol, since too short a duration might result in failure to detect weak gastric carcinogenesis and gastric promoters. Tweenty weeks is indicated to be a suitable duration in the present system to detect weak gastric prom oters.
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