The role of insulin in essential hypertensive development of Spontaneously Hypertensive Rat(SHR) is controversial. Therefore, this study was to determine whether long-term(for 10 weeks) highfructose(60%) diet feeding causes potentiation of
hyperinsulinemia and hypertension in SHR or not, and to compare the effect of feeding condition(satiety versus 24-hour fasting) in normal and fructose-enriched diet fed SHR. In the fructose-fed groups, blood pressure was increased in both satiety
and
fasting groups compared with control, respectively. And that of fasting group in fructose-fed SHR significantly decreased compared with satiety group. Together, this change was similar in normal diet-fed SHR. Similary, plasma insulin
concentration
in
fructose-fed SHR was increased in both satiety and fasting groups compared with each control. However, that of fructose-fed fasting group was similar to normal diet-fed satiety group. There was no change in plasma glucose concentration in
response
to
the fructose diet. Throughout the study there were no significant differences in body weight and hear rates between fructose-fed SHR and normal diet-fed SHR. In conclusion, satiety condition and fructose-enriched diet raise plasma insulin and
blood
pressure in SHR, and fasting caused concurrent decreases in plasma insulin and blood pressure in SHR, which suggest that feeding condition also may affect plasma insulin concentration and blood pressure, SHR, which suggest that feeding condition
also
may affect plasma insulin concentration and blood pressure, and that fructose-induced hyperinsulinemia may contribute toward the development of hypertension in the SHR
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