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KMID : 0385019970130020121
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Korean Journal of Laboratory Animal Science
1997 Volume.13 No. 2 p.121 ~ p.126
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Cyclocreatine(1-Carboxymethyl-2-iminoimidazolidine) inhibits Hpatocarcinogenesis in F344 Rat
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박상준/Park, Sang joon
조성환/정규식/민병길/이차수/지영현/류시운/Cho, Sung Hwan/Jeong, Kyu Shik/Mheen, Byoung Gil/Lee, Cha Soo/Jee, Young Heun/Ryu, Si Yun
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Abstract
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To investigate the effects of cyclocreatine(CCr), a substrate analogue of creative kinase(CK), a study was performed on the model of hepatocarcinogenesis of F344 rat with treatments of diethylnitrosamine(DEN), partial hepatectomy (PH) and 2-acetylaminofluorene(2-AAF). From 2 weeks until 14 weeks after intraperitoneal injection of DEN (200㎎/㎏), group I (N=7) was given a diet containing 0.04% 2-AAF only, group Q (N=7) was given a diet containing 0.043% 2-AAF+1% CCr, and group III (N=7) was given s basal diet after administration of 0.86% saline instead of DEN as a control group. All rate of group I, II and III were subjected to two-thirds PH at 8 weeks after DEN or saline injection and killed at 14 weeks for studying of immunoreactivity of glutathione 3-transferees placental form (GST-P). In immunohietochemical study, the number (No./㎠) and area (㎟/㎠) of GST-P positive liver foci were significantly lower in the 2-AAF+CCr treated group compared to the group treated with 2-AAF only (Mann-Whitaey U test at p$lt;0.06). We propose here that CCr supports ATP regeneration through the creative kinase systems lees efficiently than the natural substrate creative and that CCr is active against hepatocarcinogenesie rat models with elevated levels. This result points out the unique nature of an anticancer agent that inhibits progression of the chemical-induced hepatocarcinogenesie of rat.
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