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KMID : 0385020000160030195
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Korean Journal of Laboratory Animal Science
2000 Volume.16 No. 3 p.195 ~ p.200
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The Chronic Administration of Green Tea Extract Affects the Memory and Brain Neurotransmitters in Senescence-accelerated Mouse
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Han, sang seop
Lee, Hee Yong/Lee, Hye Suk/Song, Chang Woo/Yang, Sung Don/Lee, Min Jae/Lee, Ho Sub
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Abstract
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In order to study the effects of green tea on behavioral improvement, Senescence-Accelerated Mouse (SAM)- P8 and its control mouse (SAM-R1) were orally treated with green tea extracts (0.2% and 0.5%) for 6 month, and passive avoidance test was performed. The same animals used to measure the levels of neurotransmitters such as norepinephrine, dopamine and serotonin in five forebrain regions; cortex, hippocampus, striatum, cerebellum and midbrain. There was significant improvement of retention memory by the exposure of green tea extract in SAM-R1. In both strain, brain serotonin concentrations of midbrain or cortex were significantly increased by the administration of green tea extract; however, the changes of brain norepinephrine concentrations were negligible. Brain dopamine levels were significantly decreased in the hippocampus and striatum regions of SAM-P8 by green tea extract, but there was no change in SAM-R 1. These results suggest that the administration of green tea extract to SAM-R1 increases brain serotonin concentration and improves short-term memory.
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