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KMID : 0425120010390020143
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Parasites, Hosts and Diseases
2001 Volume.39 No. 2 p.143 ~ p.150
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Analysis of polymorphic regions of Plasmodium vivax Duffy binding protein of Korean isolates
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Weon Gyu Kho/Weon Gyu Kho
Joon Yong Chung/Eun Jeong Sim/Dong Wook Kim/Woo Chul Chung†
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Abstract
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The present study was designed to investigate polymorphism in Duffy binding protein (DBP) gene of Plasmodium vivax isolates of Korea. Thirty samples were obtained from P. vivax patients in Yonchon-gun, Kyonggi-do in 1998. The PCR products of the samples were subjected to sequencing and hybridization analyses of the regions II and IV of P. vivax DBP gene. Two genotypes, SK-1 and SK-2, were identified on the basis of amino acid substitution and deletion. The genotype of 10 isolates was SK-1 and that of 20 isolates was SK-2. Most of the predicted amino acids in the region II of DBP gene were conserved between the Korean isolates and Belem strain except for 4-5 amino acid substitutions. In the region IV of DBP, a 6-bp insert that was shown in the Sal-1 allele type was found in SK-1, and a 27-bp insert that was shown in the Papua New Guinea allele type was found in SK-2. In conclusion, the present findings suggest that two genotypes of P. vivax coexist in the endemic area of Korea.
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KEYWORD
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Plasmodium vivax, Duffy binding protein, genotype, polymorphism, Korean isolates,
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