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KMID : 0425120020400020093
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Parasites, Hosts and Diseases
2002 Volume.40 No. 2 p.93 ~ p.99
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Degradation of immunoglobulins, protease inhibitors, and interleukin-1 by a secretory proteinase of Acanthamoeba castellanii
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Tong Soo Kim/Byoung Kuk Na
Jung Hwa Cho/Chul Yong Song/Tong Soo Kim
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Abstract
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The effect of a secretory proteinase from the pathogenic amoebae Acanthamoeba castellanii on host's defense-oriented or regulatory proteins such as immunoglobulins, interleukin-1, and protease inhibitors was investigated. The enzyme was found to degrade secretory immunoglobulin A (sIgA), IgG, and IgM. It also degraded interleukin-1α (IL-1α) and IL-1β. Its activity was not inhibited by endogenous protease inhibitors, such as α2-macroglobulin, α1-trypsin inhibitor, and α2-antiplasmin. Furthermore, the enzyme rapidly degraded those endogenous protease inhibitors as well. The degradation of host's defense-oriented or regulatory proteins by the Acanthamoeba proteinase suggested that the enzyme might be an important virulence factor in the pathogenesis of Acanthamoeba infection.
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KEYWORD
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Acanthamoeba, protease inhibitors, immunoglobulins, interleukin-1,
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