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KMID : 0425120070450030239
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Parasites, Hosts and Diseases
2007 Volume.45 No. 3 p.239 ~ p.243
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Validity of MAST-CLA for diagnosis of arthropod allergy using receiver operating characteristic (ROC) analysis
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Park Joon-Soo
Nam Hae-Seon
Kim Yong-Bae
Choi Young-Jin
Lee Sang-Han
Kim Sung-Ho
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Abstract
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Many allergists are currently focusing on the development of new diagnostic tools, and are attempting to improve both the sensitivity and specificity. A multiple allergen simultaneous test-chemiluminescent assay (MAST-CLA) is one of the most popular diagnostic tools used in the Republic of Korea. However, there remains controversy among allergists with regard to the cut-off point for a positive result. The present study was conducted in order to determine the validity of MAST-CLA as compared with that of the skin prick test, with particular emphasis on arthropod allergens, on the basis of percentage agreement rates and k-values, and also to suggest the optimal positive cutoff points using receiver operating characteristic (ROC) curves. The study was conducted with 97 subjects (54 men, 43 women). Optimal individual cut-off points were calculated as follows; class II for Dermatophagoides farinae, class I for Dermatophagoides pteronyssinus, and trace for a cockroach mix. These findings suggest that attempting to apply optimal individual cut-off points will be a good way of improving diagnostic tests, particularly MAST-CLA.
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KEYWORD
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Dermatophagoides farinae, Dermatophagoides pteronyssinus, allergy, arthropod, skin prick test, MAST-CLA, ROC, cut-off point
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