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KMID : 0425120080460010017
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Parasites, Hosts and Diseases
2008 Volume.46 No. 1 p.17 ~ p.22
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Changing Patterns of Serum and Bile Antibodies in Re-infected Rats with Clonorchis sinensis
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Zhang Hong-Man
Hong Sung-Tae
Choi Min-Ho
Chung Byung-Suk
Li Shunyu
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Abstract
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Rats develop strong resistance to re-infection and super-infection by Clonorchis sinensis. The present study investigated the antibodies present in the sera and bile juice of rats that were primary infected and re-infected with C. sinensis. The serum level of specific IgG antibodies, which were elevated 2 wk of the primary infection, peaked at 4 wk and subsequently remained unchanged even during re-infection. The total IgE level in serum increased slowly from 388 ng / ml to 3,426 ng / ml beginning 2 wk after the primary infection, and remained high up to 8 wk but dropped to a normal level (259 ng / ml) after treatment. In resistant re-infected rats, the serum IgE level increased rapidly and peaked within 1 wk, whereas no increase was observed in immunosuppressed rats. The serum level of specific IgA antibodies was elevated beginning 1 wk after infection, and decreased 4 wk after treatment. The total bile IgA level unchanged during the primary infection but increased in treated and re-infected rats. The elevated levels of serum IgE and bile IgA indicate that these immunoglobulins may be correlated with the development of resistance to re-infection by C. sinensis in rats.
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KEYWORD
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Clonorchis sinensis, Serum, Bile juice, IgA, IgE, Rat, Re-infection
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