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KMID : 0425120080460030195
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Parasites, Hosts and Diseases
2008 Volume.46 No. 3 p.195 ~ p.198
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High Levels of Antibodies to Plasmodium falciparum Liver Stage Antigen-1 in Naturally Infected Individuals in Myanmar
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Lee Hyeong-Woo
Kim Tong-Soo
Na Byung-Kuk
Cho Shin-Hyeong
Moon Sung-Ung
Kim Yeon-Joo
Lin Khin
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Abstract
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Plasmodium falciparum liver stage antigen-1 (PfLSA-1) is one of the few antigens expressed exclusively in liver stage parasites. In this study, we evaluated the antibody responses against recombinant PfLSA-1 in naturally infected individuals in Myanmar. High levels of antibody responses (70.7%) were detected in 82 serum samples from 116 infected individuals, and IgG responses to PfLSA-1 principally composed of responses of IgG1 and IgG3 subclasses. These results show that PfLSA-1 elicits effective antibody responses in individuals infected with P. falciparum, and thus it could be not only an attractive candidate protein for vaccine development, but also a useful antigen for serodiagnosis of the infection.
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KEYWORD
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Plasmodium falciparum, liver stage malaria antigen, recombinant protein, antibody response, Myanmar
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